BACKGROUND AND AIM[|]Ambient air pollution remains a global public health concern. Exposure to air pollution is associated with numerous adverse respiratory effects in vulnerable groups such as children. Over the past few years, Edmonton has experienced an increasing number of poor air quality days due to wildfire activity in Alberta, Canada and neighboring states and provinces. The aim of this study was to investigate the association between exposure to air pollution from the wildfires in and around Alberta, Canada, and respiratory visits to emergency departments (ED) among children from 2016 to 2018.[¤]METHOD[|]Time-series regression analysis with negative binomial regression was used to explore associations between daily pollutants; carbon monoxide (CO), nitrogen dioxide (NO2), ozone (O3), fine particulate matter (PM2.5), and sulfur dioxide (SO2), and daily respiratory emergency visits among children (under 17 years old) in the Edmonton area between 2016 and 2018, a period of heightened wildfire smoke activity[¤]RESULTS[|]There were 8,250 emergency department (ED) visits for respiratory diseases among children between 2016 and 2018 in Edmonton, Canada. During wildfire seasons, the daily respiratory ED visits among children were significantly, associated exposure to CO, with an IRR of 1.20 (95%CI: 1.02-1.40). Additionally, there was significant evidence showing associations between daily respiratory ED visits among children and exposure to NO2, with an IRR of 1.08 (95%CI: 1.01-1.16). Exposure to O3, was found to be positively associated with daily respiratory ED visits among children, with an IRR of 1.12 (95%CI: 0.997-1.26). Lastly exposure to PM2.5 was positively associated with daily respiratory ED visits among children, with an IRR of 1.06 (95%CI: 1.00-1.11).[¤]CONCLUSIONS[|]The study showed adverse associations between air pollution levels and increases in daily respiratory ED visits among children under 17 years old in Edmonton between 2016 and 2018. Further studies are needed to address knowledge gaps on the health impacts of wildfires.[¤]